Reaktion #2362428

Reaktionsgleichung

9-Ethyl-6,6-dimethyl-11-oxo-8-piperazin-1-yl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

cyclohexanone

trimethylsilyl cyanide

→

title compound

Ausbeute 30.0%

8-[4-(1-Cyano-cyclohexyl)-piperazin-1-yl]-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Ausbeute 30.0%

Lösungsmittel

chloroform

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe organic layer was washed with 10% brine solution
2. 2
   Einengenconcentrated under reduced pressure
3. 3
   SonstigeThe resulting residues were purified by silica gel column (dichloromethane/methanol (=99/1))

Vorschrift

9-Ethyl-6,6-dimethyl-11-oxo-8-piperazin-1-yl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile (45 mg) and cyclohexanone (25 mg) were suspended in chloroform (2 ml), added with trimethylsilyl cyanide (30 mg) and zinc iodide (5 mg), and the mixture was stirred at 60° C. for 17 hrs. The reaction mixture was diluted with ethyl acetate (20 ml) and the organic layer was washed with 10% brine solution and concentrated under reduced pressure. The resulting residues were purified by silica gel column (dichloromethane/methanol (=99/1)) to obtain the title compound (12 mg, yield 30%).

Quelle