Reaktion #2360262

Reaktionsgleichung

2-amino-4-methoxypyridine

triphosgene

4-(4-aminophenyl)-6,8,8-trimethyl-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

triethylamine

→

1-(4-methoxypyridin-2-yl)-3-{4-[6,8,8-trimethyl-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]phenyl}urea

Ausbeute 29.8%

Lösungsmittel

DCM

DCM

DCM MeOH pentane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONThis mixture is then added under nitrogen to a solution
2. 2
   workup.STIRRINGThis mixture is stirred for 2 hours at room temperature
3. 3
   Extraktionextracted with DCM
4. 4
   Waschenwashed once with water
5. 5
   Trocknenwith saturated NaCl solution, and the organic phase is dried over Na2SO4
6. 6
   FiltrationThe resulting phase is filtered
7. 7
   Sonstigethe filtrate is evaporated under reduced pressure
8. 8
   SonstigeThe residue is chromatographed on silica gel
9. 9
   Wascheneluting with a DCM/MeOH mixture from (100/0 v/v) up to (100/4 v/v)
10. 10
    SonstigeThe solid obtained
11. 11
    Filtrationfiltered off
12. 12
    Sonstigedried

Vorschrift

210 mg (0.51 mmol) of 4-(4-aminophenyl)-6,8,8-trimethyl-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one and 314.5 mg (3 mmol) of triethylamine are added to 3 ml of DCM. This mixture is then added under nitrogen to a solution containing 152.2 mg (0.51 mmol) of triphosgene in 3 ml of DCM. The mixture is stirred at room temperature for 30 minutes, and 268.1 mg (2 mmol) of 2-amino-4-methoxypyridine are then added. This mixture is stirred for 2 hours at room temperature, extracted with DCM, washed once with water and then with saturated NaCl solution, and the organic phase is dried over Na2SO4. The resulting phase is filtered and the filtrate is evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a DCM/MeOH mixture from (100/0 v/v) up to (100/4 v/v). The solid obtained is then taken up in a DCM/MeOH/pentane mixture, filtered off and dried to give 85 mg of 1-(4-methoxypyridin-2-yl)-3-{4-[6,8,8-trimethyl-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]phenyl}urea.

Quelle