Reaktion #2360249

Reaktionsgleichung

triethylamine

tert-butyl 3-bromopropionate

1-aminomethylpropan-2-ol

→

3-(2-hydroxy-2-methylpropylamino)propionic acid tert-butyl ester

Ausbeute 82.0%

Lösungsmittel

DMF

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONare successively added dropwise
2. 2
   Sonstigethe solvent is evaporated off
3. 3
   SonstigeThe residue is chromatographed on silica gel with a gradient of from 0% to 20% MeOH in DCM

Vorschrift

1 g of 1-aminomethylpropan-2-ol (11.22 mmol) is placed in 10 ml of DMF. 1.58 ml of triethylamine (11.22 mmol) and 1.87 ml of tert-butyl 3-bromopropionate (11.22 mmol) prediluted in 5 ml of DMF are successively added dropwise. After stirring for 18 hours at room temperature, the solvent is evaporated off. The residue is chromatographed on silica gel with a gradient of from 0% to 20% MeOH in DCM to give 2 g of 3-(2-hydroxy-2-methylpropylamino)propionic acid tert-butyl ester.

Quelle