Reaktion #2358525

Reaktionsgleichung

tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate

HCl

NaOH

→

title compound

Ausbeute 78.6%

2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethanamine

Ausbeute 78.6%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate (2×100 ml)
2. 2
   WaschenThe combined organic phase was washed with brine (75 ml)
3. 3
   Trocknendried (Na2SO4)
4. 4
   Sonstigeevaporated

Vorschrift

A mixture of tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate (1.4 g, 4.2 mmol) in EtOH (18 ml) was added HCl (1.25 M in EtOH, 6 ml). The mixture was stirred at ambient temperature for 20 h. The aqueous phase was made basic by addition of aqueous NaOH (1 M, 50 ml) and extracted with ethyl acetate (2×100 ml). The combined organic phase was washed with brine (75 ml), dried (Na2SO4) and evaporated to yield the title compound (0.77 g, 77%). MS m/z (relative intensity, 70 eV 298 (M+, 18), 296 (M+, 18), 109 (bp), 107 (99), 82 (15).

Quelle