Reaktion #2358519

ord-4c60851f06e74ea68f8fbb7073454037

Reaktionsgleichung

CCCNCCOc1cc(F)cc(S(C)(=O)=O)c1
( 2 )
CCCNCCOc1cc(F)cc(S(C)(=O)=O)c1
N-{2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl}-N-propylamine
CS(=O)(=O)c1cc(F)cc(OCCBr)c1
1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene
NCC1CC1
aminomethylcyclopropane
→
CS(=O)(=O)c1cc(F)cc(OCCNCC2CC2)c1
N-(cyclopropylmethyl)-N-{2-[3-fluoro-5-(methylsulfonyl)-phenoxy]ethyl}amine

Edukte

CCCNCCOc1cc(F)cc(S(C)(=O)=O)c1
( 2 )
CCCNCCOc1cc(F)cc(S(C)(=O)=O)c1
N-{2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl}-N-propylamine
CS(=O)(=O)c1cc(F)cc(OCCBr)c1
1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene
NCC1CC1
aminomethylcyclopropane
—
( 14 )
—
( 6 )

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePreparation

Vorschrift

Preparation according to Example 1 but performed in one portion: 1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene (0.05 g, 0.16 mmol) and aminomethylcyclopropane (0.11 ml, 1.3 mmol) in ethanol (5 ml). MS m/z (relative intensity, 70 eV) 287 (M+, 2), 246 (6), 138 (2), 84 (bp), 56 (14).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09120728B2uspto-grants-2015_09