Reaktion #2358258

Reaktionsgleichung

ethanesulfonyl chloride

5-amino-2,3,4,5-tetrahydro-1-benzoxepine

triethylamine

→

5-ethylsulfonylamino-2,3,4,5-tetrahydro-1-benzoxepine

Ausbeute 70.6%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto come to room temperature
2. 2
   workup.DISTILLATIONthe solvent was distilled off in vacuo
3. 3
   workup.STIRRINGAfter stirring the residue with water
4. 4
   Filtrationthe deposited product was filtered off with suction

Vorschrift

0.86 g (6.7 mmol) of ethanesulfonyl chloride was added dropwise with ice cooling to a solution of 1.0 g (6.1 mmol) of 5-amino-2,3,4,5-tetrahydro-1-benzoxepine and 2.5 g (24 mmol) of triethylamine in 20 ml of THF. The mixture was allowed to come to room temperature and was stirred overnight, and the solvent was distilled off in vacuo. After stirring the residue with water, the deposited product was filtered off with suction. 1.1 g of 5-ethylsulfonylamino-2,3,4,5-tetrahydro-1-benzoxepine were obtained, m.p. 109-111° C.

Quelle