Reaktion #2354769
ord-a7dcfc659d384a09a12b7236b23168b9
Reaktionsgleichung
5-phenyl-3-(4-piperidinyl)-1H-indole-7-carboxamide
2,4-dimethyl-1,3-thiazole-5-sulfonyl chloride
triethylamine
TEA
→
desired product
3-{1-[(2,4-dimethyl-1,3-thiazol-5-yl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Aufarbeitung
- 1Sonstigewere reacted
Vorschrift
Following the general procedure in example 267, 5-phenyl-3-(4-piperidinyl)-1H-indole-7-carboxamide (32 mg, 0.1 mmol), 2,4-dimethyl-1,3-thiazole-5-sulfonyl chloride (24.8 mg, 0.15 mmol) and triethylamine (0.06 mL, 0.3 mmol) were reacted to form the desired product which was purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) (12.7 mg, 26%).