Reaktion #2354763

Reaktionsgleichung

5-(phenyl)-3-(4-piperidinyl)-1H-indole-7-carboxamide

2-(acetylamino)-4-methyl-1,3-thiazole-5-sulfonyl chloride

triethylamine

TEA

→

desired product

3-(1-{[2-(acetylamino)-4-methyl-1,3-thiazol-5-yl]sulfonyl}-4-piperidinyl)-5-phenyl-1H-indole-7-carboxamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewere reacted

Vorschrift

Following the general procedure in example 267, 5-(phenyl)-3-(4-piperidinyl)-1H-indole-7-carboxamide (32 mg, 0.1 mmol), 2-(acetylamino)-4-methyl-1,3-thiazole-5-sulfonyl chloride (38.2 mg, 0.15 mmol) and triethylamine (0.06 mL, 0.3 mmol) were reacted to form the desired product which was purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) (4.0 mg, 7.5%).

Quelle