Reaktion #2353630

Reaktionsgleichung

7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-ol

5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-ol

N-phenyltrifluoromethanesulfonimide

potassium carbonate

trifluoromethanesulfonic acid 5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-yl ester

→

title compound

Trifluoromethanesulfonic Acid 7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl Ester

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered
2. 2
   Einengenthe filtrate concentrated under reduced pressure
3. 3
   SonstigePurification of the residue by column chromatography on silica gel
4. 4
   Wascheneluting with 1,2-dichloroethane
5. 5
   Sonstigegave

Vorschrift

A mixture of 7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-ol and 5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-ol (0.66 g), N-phenyltrifluoromethanesulfonimide (0.86 g), potassium carbonate (0.82 g) and tetrahydrofuran (10 mL) was heated by microwave irradiation at 130° C. for 20 minutes. The mixture was filtered and the filtrate concentrated under reduced pressure. Purification of the residue by column chromatography on silica gel, eluting with 1,2-dichloroethane gave a 50:50 mixture of title compound and trifluoromethanesulfonic acid 5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-yl ester as a honey coloured gum, 0.86 g.

Quelle