Reaktion #2353629

Reaktionsgleichung

3-amino-5-chlorophenol

3-(4-chlorobenzyl)pentane-2,4-dione

p-toluenesulfonic acid monohydrate

5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-ol

→

title compound

7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-ol

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to room temperature
2. 2
   Sonstigesonicated
3. 3
   FiltrationThe resulting precipitate was collected by filtration
4. 4
   Waschenwashed with methanol
5. 5
   Sonstigedried
6. 6
   Sonstigeto afford

Vorschrift

A mixture of 3-amino-5-chlorophenol (0.46 g), 3-(4-chlorobenzyl)pentane-2,4-dione (0.72 g), and p-toluenesulfonic acid monohydrate (0.26 g) was heated at 160° C. for 2 hours. The mixture was cooled to room temperature, diluted with methanol (5.0 mL) and sonicated. The resulting precipitate was collected by filtration, washed with methanol and dried to afford a 50:50 mixture of title compound and 5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-ol as an off-white solid, 0.67 g.

Quelle