Reaktion #2350928

ord-2a325b65c0fb46009ec01db3c9480846

Reaktionsgleichung

CCOC(=O)c1nc(NC(=O)N(C2CCCCC2)C2CCCCC2)sc1SC#N
2-(3,3-dicyclohexyl-ureido)-5-thiocyanato-thiazole-4-carboxylic acid ethyl ester
CI
methyl iodide
CSc1sc(NC(=O)N(C2CCCCC2)C2CCCCC2)nc1C(=O)O
title compound
CSc1sc(NC(=O)N(C2CCCCC2)C2CCCCC2)nc1C(=O)O
2-(3,3-Dicyclohexyl-ureido)-5-methylsulfanyl-thiazole-4-carboxylic acid
CCOC(=O)c1nc(NC(=O)N(C2CCCCC2)C2CCCCC2)sc1SC
2-(3,3-Dicyclohexyl-ureido)-5-methylsulfanyl-thiazole-4-carboxylic acid ethyl ester

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeHydrolysis

Vorschrift

2-(3,3-Dicyclohexyl-ureido)-5-methylsulfanyl-thiazole-4-carboxylic acid ethyl ester was prepared as described in general procedure (H) using 2-(3,3-dicyclohexyl-ureido)-5-thiocyanato-thiazole-4-carboxylic acid ethyl ester and methyl iodide. Hydrolysis using general procedure (F) gave the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07851636B2uspto-grants-2010_12