Reaktion #2348125

Reaktionsgleichung

3-methoxythioanisole

oxone

acetone

→

1-methanesulfonyl-3-methoxy benzene

Ausbeute 98.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeresulting in the formation of a white precipitate
2. 2
   Filtrationthe solid was filtered off
3. 3
   Waschenwashed with acetone
4. 4
   EinengenFiltrate was concentrated
5. 5
   Sonstigeto remove acetone
6. 6
   ExtraktionAqueous layer was extracted with EtOAc (2×200 mL)
7. 7
   Trocknendried over Na2SO4
8. 8
   SonstigeThe solvent was removed

Vorschrift

To a solution of 3-methoxythioanisole (3.084 g, 20 mmol) in 300 mL acetone was added a solution of oxone (30.74 g, 50 mmol) in 125 mL water, resulting in the formation of a white precipitate. Stirring continued overnight, and the solid was filtered off and washed with acetone. Filtrate was concentrated to remove acetone. Aqueous layer was extracted with EtOAc (2×200 mL) and dried over Na2SO4. The solvent was removed to give 1-methanesulfonyl-3-methoxy benzene (3.68 g, 98%) as oil.

Quelle