Reaktion #2345675

Reaktionsgleichung

CBZ-L-Pro-Cl

2-(2,2,3,3,3-pentafluoro-1-oxopropyl)pyrrolidine hydrochloride

N-methylmorpholine

→

desired product

2-[[2-(2,2,3,3,3-pentafluoro-1-oxopropyl)-1-pyrrolidinyl]carbonyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

Lösungsmittel

methylene chloride

Methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter 2.5 hours the reaction was concentrated
2. 2
   Sonstigethe product purified by flash chromatography on silica gel column
3. 3
   Wascheneluting with ethyl acetate/hexane (50:50)
4. 4
   SonstigeProduct fractions were collected
5. 5
   Einengenconcentrated

Vorschrift

Methylene chloride (10 ml) was added to CBZ-L-Pro-Cl which was then reacted under argon with a suspension of 2-(2,2,3,3,3-pentafluoro-1-oxopropyl)pyrrolidine hydrochloride (compound from Example IC; 2.49 mmol) and N-methylmorpholine (0.54 ml; 4.98 mmol) dissolved in methylene chloride (7 ml). After 2.5 hours the reaction was concentrated and brought up in methylene chloride (1 ml) and the product purified by flash chromatography on silica gel column eluting with ethyl acetate/hexane (50:50). Product fractions were collected and concentrated to give the desired product (0.52 g) as a colorless oil.

Quelle