Reaktion #2345348

Reaktionsgleichung

n-propyl bromide

magnesium

4'-(4-fluoro-4-silacyclohexyl)-3,4,5-trifluorobiphenyl

→

4'-(trans-4-n-propyl-4-silacyclohexyl)-3,4,5-trifluorobiphenyl

Ausbeute 91.0%

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto obtain a Grignard's reagent

Vorschrift

2.5 g (20 mmol) of n-propyl bromide was dripped into a mixture of 0.5 g of magnesium (21 mmol) and 50 ml of THF to obtain a Grignard's reagent. This solution was then dripped into a 50 ml THF solution of 6.5 g (20 mmol) of 4'-(4-fluoro-4-silacyclohexyl)-3,4,5-trifluorobiphenyl to obtain 4'-(trans-4-n-propyl-4-silacyclohexyl)-3,4,5-trifluorobiphenyl. The silacyclohexane rings of this product were a mixture of trans and cis isomers. They were separated by means of chromatography to obtain 5.9 g of the trans isomer (yield 91%).

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