Reaktion #2342671

Reaktionsgleichung

5-cyano-3,4-dichloroisothiazole

sulfuric acid

isothiazole

→

3,4-dichloro-5-isothiazolecarboxylic acid amide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was cooled under ice cooling
2. 2
   Sonstigeprecipitated crystals
3. 3
   Filtrationwere collected by filtration
4. 4
   SonstigeThe crystals were then recrystallized from a 1:1 mixed solvent of ethanol and water

Vorschrift

Concentrated sulfuric acid (10 ml) was added to 1.0 g of 5-cyano-3,4-dichloroisothiazole. When heated at 110° C. for 20 minutes, the isothiazole compound was dissolved completely. The reaction mixture was cooled under ice cooling, and precipitated crystals were collected by filtration. The crystals were then recrystallized from a 1:1 mixed solvent of ethanol and water.

Quelle