Reaktion #2342588

Reaktionsgleichung

sodium azide

1-[4,6-bis(1,1-dimethylethyl)-5-hydroxy-2-pyrimidinyl]-2-bromo-1-propanone

→

azide

Ausbeute 96.2%

2-Azido-1-[4,6-bis(1,1-dimethylethyl)-5-hydroxy-2-pyrimidinyl]-1-propanone

Ausbeute 96.2%

Lösungsmittel

water

acetone

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   WaschenThe organic layers were washed with brine
3. 3
   Trocknendried (anhydrous sodium sulfate)
4. 4
   Sonstigeevaporated

Vorschrift

A solution of 1.2 g (18 mmol) of sodium azide in 9.0 mL of water was added dropwise to a solution of 5.5 g (16 mmol) of 1-[4,6-bis(1,1-dimethylethyl)-5-hydroxy-2-pyrimidinyl]-2-bromo-1-propanone in 35 mL of acetone. The mixture was stirred for 2 hours then added to 100 mL of water and extracted with ethyl acetate. The organic layers were washed with brine, dried (anhydrous sodium sulfate), and evaporated to yield 4.7 g (96%) of the azide product, mp 91° C.-92° C., suitable for further synthesis.

Quelle