Reaktion #2342

Reaktionsgleichung

Sodium hydride

4-[4-(4-pyridyl)piperazin-1-yl]phenol

Allyl chloride

→

4-[4-(4-pyridyl)piperazin-1-yl]phenol allyl ether

Ausbeute 85.7%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITcontinued for 20 hours
3. 3
   Extraktionthe mixture extracted three times with ethyl acetate
4. 4
   WaschenThe combined extracts were washed with water and brine
5. 5
   Trocknendried (MgSO4)
6. 6
   Sonstigeevaporated
7. 7
   SonstigeThe residue was triturated with hexane
8. 8
   Filtrationfiltered

Vorschrift

Sodium hydride (60% dispersion in mineral oil, 0.4 g) was added to a stirred suspension of 4-[4-(4-pyridyl)piperazin-1-yl]phenol (2.55 g) in DMF (25 ml) and the mixture stirred for 20 minutes at room temperature. Allyl chloride (0.756 g) was added dropwise and stirring continued for 20 hours. Ice-water (75 ml) was added and the mixture extracted three times with ethyl acetate. The combined extracts were washed with water and brine, dried (MgSO4) and evaporated. The residue was triturated with hexane and filtered to give 4-[4-(4-pyridyl)piperazin-1-yl]phenol allyl ether (2.5 g) as a solid;

Quelle