Reaktion #2338019

Reaktionsgleichung

intermediate 1

2-fluoro-5H-dibenzo[a,d]cycloheptene

Metachloroperbenzoic acid

→

3-fluoro-6,10b-dihydro-1aH-dibenzo-[3,4:6,7]cyclohept[1,2-b]oxirene

Ausbeute 110.4%

Lösungsmittel

CHCl3

CHCl3

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic solution was dried
2. 2
   Filtrationfiltered
3. 3
   workup.STIRRINGThe reaction mixture was stirred for 2.5 hours at 60° C.
4. 4
   Temperaturcooled on an ice-bath
5. 5
   Waschenwashed with a 10% aqueous Na2CO3 solution and brine
6. 6
   Sonstigedried
7. 7
   Filtrationfiltered
8. 8
   Sonstigethe filtrate was evaporated

Vorschrift

Metachloroperbenzoic acid (0.0501 mol) was dissolved in CHCl3 (40 ml). The organic solution was dried, filtered and the filtrate was added dropwise to a solution of intermediate 1 (0.0417 mol) and 1,4-benzenediol (0.26 g) in CHCl3 (70 ml), stirred at 60° C. The reaction mixture was stirred for 2.5 hours at 60° C., then cooled on an ice-bath, washed with a 10% aqueous Na2CO3 solution and brine, dried, filtered and the filtrate was evaporated, yielding 10.42 g of 3-fluoro-6,10b-dihydro-1aH-dibenzo-[3,4:6,7]cyclohept[1,2-b]oxirene (intermediate 2)

Quelle