Reaktion #2336526

Reaktionsgleichung

4-hydroxypiperidine

phenylpropionyl chloride

phenylpropionic acid

NaOH

→

1-(3-phenylpropionyl)-4-hydroxypiperidine

Ausbeute 39.0%

Lösungsmittel

toluene

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe aqueous phase was extracted with CH2Cl2
2. 2
   Sonstigedried
3. 3
   Sonstigeevaporated under vacuum

Vorschrift

This amine was synthesized in accordance with the method of Scheme 37. To 4 g (40 mmol) of 4-hydroxypiperidine in 20 mL of toluene was added phenylpropionyl chloride (derived from 6 g (40 mmol) of phenylpropionic acid in excess thionyl chloride). To the mixture was added excess 2N aqueous NaOH. After stirring 24 hours, the toluene layer was discarded and the aqueous phase was extracted with CH2Cl2, dried, and evaporated under vacuum to give 3.63 g (39%) of 1-(3-phenylpropionyl)-4-hydroxypiperidine (134). GC/MS indicated 100% purity with a molecular ion of 233.

Quelle