Reaktion #2336518

Reaktionsgleichung

Ethyl 4-hydroxypyrimidine-5-carboxylate

LiOH.H2O

→

title compound 19

4-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID

Lösungsmittel

THF

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was quenched with conc. HCl (1 mL)
2. 2
   Extraktionextracted with EtOAc (2×20 mL)
3. 3
   ExtraktionThe combined organic extract
4. 4
   Trocknenwas dried (MgSO4)
5. 5
   Einengenconcentrated

Vorschrift

Ethyl 4-hydroxypyrimidine-5-carboxylate can be prepared following the procedure of M. Pesson et al., Eur. J. Med. Chem.—Chim. Ther. 1974, 9, 585. A solution of this ester (500 mg, 3 mmol) in THF (10 mL) and MeOH (5 mL) was treated with LiOH.H2O (373 mg, 8.9 mmol) and stirred overnight. The mixture was quenched with conc. HCl (1 mL) and extracted with EtOAc (2×20 mL). The combined organic extract was dried (MgSO4) and concentrated to give 260 mg of the title compound 19 as an orange solid, m.p. 220° C. (dec). 4-HYDROXY-2-METHYLPYRIMIDINE-5-CARBOXYLIC ACID (20).

Quelle