Reaktion #2335305

Reaktionsgleichung

Cyclopropylmethyl bromide

6,12-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-8H-pyrrolo[2,3-i][3]benzazocine

dimethylformamide

diisopropylethyl amine

→

product

Ausbeute 23.0%

3-Cyclopropylmethyl-6,12-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-8H-pyrrolo-[2,3-i][3]benzazocine

Ausbeute 23.0%

Lösungsmittel

water

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction mixture was heated at 82°-83° C. for 6 hr
2. 2
   SonstigeThe layers were separated
3. 3
   Extraktionthe aqueous layer extracted with ethyl acetate and ether
4. 4
   WaschenThe combined organic layers were washed with water and brine
5. 5
   Trocknendried over anhydrous potassium carbonate
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated
8. 8
   SonstigeThe residue was purified by flash column chromatography (silica gel, 2% triethylamine/0-15% methanol/ethyl acetate)

Vorschrift

To a stirred solution of 0.99 g of 6,12-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-8H-pyrrolo[2,3-i][3]benzazocine and 18 ml of dimethylformamide was added 1.44 ml of diisopropylethyl amine. Cyclopropylmethyl bromide (0.48 ml) was added, under nitrogen, and the reaction mixture was heated at 82°-83° C. for 6 hr. The reaction mixture was cooled to room temperature and was poured into ethyl acetate and water. The layers were separated and the aqueous layer extracted with ethyl acetate and ether. The combined organic layers were washed with water and brine, dried over anhydrous potassium carbonate, filtered, and concentrated. The residue was purified by flash column chromatography (silica gel, 2% triethylamine/0-15% methanol/ethyl acetate), a second column (silica gel, 2% triethylamine/ethyl acetate), and a third column (silica gel, 1% triethylamine/ether) to afford 0.28 g (23%) of the product, as an oil, which crystallized upon trituration with ether. Recrystallization from ether-pentane gave the analytical sample, mp 164°-166° C.

Quelle