Reaktion #2335258

Reaktionsgleichung

2-(4-nitrophthalimido)acetic acid

phosphorus pentachloride

→

title compound

Ausbeute 99.0%

2-(4-Nitrophthalimido)acetyl chloride

Ausbeute 99.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed for 3 hours
2. 2
   SonstigeAfter completion of the reaction
3. 3
   Sonstigethe solvent was removed under reduced pressure
4. 4
   workup.ADDITIONBy addition of hexane to the residue

Vorschrift

To a suspension of 2-(4-nitrophthalimido)acetic acid (58.6 g) in toluene (250 ml) was added phosphorus pentachloride (48.8 g) and the mixture was refluxed for 3 hours. After completion of the reaction, the solvent was removed under reduced pressure. By addition of hexane to the residue, the title compound (62.3 g) was obtained as light yellow sharp-pointed needles.

Quelle