Reaktion #2333244

ord-9622cd16fef84ac38b55ca7256e51d5c

Reaktionsgleichung

Br.OC1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1
1-[bis(4-chlorophenyl)methyl]azetidin-3-ol hydrobromide
CS(=O)(=O)Nc1ccc2ncccc2c1
N-quinolin-6-ylmethanesulfonamide
CC(C)OC(=O)/N=N/C(=O)OC(C)C
DIAD
c1ccc(P(c2ccccc2)c2ccccc2)cc1
triphenylphosphine
→
CS(=O)(=O)N(c1ccc2ncccc2c1)C1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1
N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-quinol-6-yl-methylsulfonamide

Edukte

Br.OC1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1
1-[bis(4-chlorophenyl)methyl]azetidin-3-ol hydrobromide
CS(=O)(=O)Nc1ccc2ncccc2c1
N-quinolin-6-ylmethanesulfonamide
CC(C)OC(=O)/N=N/C(=O)OC(C)C
DIAD
c1ccc(P(c2ccccc2)c2ccccc2)cc1
triphenylphosphine

Reagenzien

Keine

Lösungsmittel

Cc1ccccc1
toluene

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

reaction of 1-[bis(4-chlorophenyl)methyl]azetidin-3-ol hydrobromide with N-quinolin-6-ylmethanesulfonamide in the presence of DIAD and triphenylphosphine in toluene, to form N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-quinol-6-yl-methylsulfonamide (the reaction is preferably performed at a temperature of between 40 and 60° C.), and then

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07687493B2uspto-grants-2010_03