Reaktion #2331585

Reaktionsgleichung

2-methyl-thiazole-4-carboxylic acid ethyl ester

NaOH

→

2-Methyl-thiazole-4-carboxylic acid

Ausbeute 87.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeMethanol was removed in vacuo
2. 2
   ExtraktionThe aqueous phase was then extracted three times with ethyl acetate
3. 3
   TrocknenThe combined organic layers were dried with sodium sulphate
4. 4
   Sonstigeevaporated

Vorschrift

A solution of 2-methyl-thiazole-4-carboxylic acid ethyl ester (3.14 g, 20.00 mmol) in methanol (50.00 ml) was treated with 2N NaOH (30.00 ml) and stirred at room temperature for 45 min. Methanol was removed in vacuo and the resulting slurry was neutralized with HCl 2N (30.00 ml). The aqueous phase was then extracted three times with ethyl acetate. The combined organic layers were dried with sodium sulphate and evaporated. 2-Methyl-thiazole-4-carboxylic acid (2.48 g, 87%) was obtained as a yellow solid, MS (ISP): m/e=142.1 (M−H), which was used crude.

Quelle