Reaktion #2330969

ord-a785069e7b9a4229bbe4913479bd65e7

Reaktionsgleichung

CCOc1cc2c(cc1OC)C(c1ccc(C(=O)N(C(C)C)C(C)C)cc1)=N[C@@H]1CCN(C)C[C@H]21
Pumafentrin
Nc1nc2c(=O)n(CC3CC3)c(=O)n(CC3CC3)c2[nH]1
Cipamfylline
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
roflumilast
CCCOc1cc([C@]2(C)CNC(=O)O2)ccc1OC
Mesopram
Cn1c(=O)c2[nH]cnc2n(C)c1=O
theophylline
CC(C)Cn1c(=O)n(C)c(=O)c2nc[nH]c21
isobutylmethylxanthine
COc1cc(-c2ccc(=O)[nH]n2)ccc1OC(F)F
Zardaverine
CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32
vinpocetine
CCCn1c(=O)c2nc[nH]c2n(-c2ccc(Cl)cc2)c1=O
Arofylline
COc1ccc(C2CNC(=O)NC2)cc1O[C@H]1C[C@@H]2CC[C@H]1C2
atizoram
COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1
Rolipram
→
Cn1c(=O)c2c(ncn2CC2OCCO2)n(C)c1=O
Doxofylline

Edukte

CCOc1cc2c(cc1OC)C(c1ccc(C(=O)N(C(C)C)C(C)C)cc1)=N[C@@H]1CCN(C)C[C@H]21
Pumafentrin
Nc1nc2c(=O)n(CC3CC3)c(=O)n(CC3CC3)c2[nH]1
Cipamfylline
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
roflumilast
CCCOc1cc([C@]2(C)CNC(=O)O2)ccc1OC
Mesopram
Cn1c(=O)c2[nH]cnc2n(C)c1=O
theophylline
CC(C)Cn1c(=O)n(C)c(=O)c2nc[nH]c21
isobutylmethylxanthine
COc1cc(-c2ccc(=O)[nH]n2)ccc1OC(F)F
Zardaverine
CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32
vinpocetine
CCCn1c(=O)c2nc[nH]c2n(-c2ccc(Cl)cc2)c1=O
Arofylline
COc1ccc(C2CNC(=O)NC2)cc1O[C@H]1C[C@@H]2CC[C@H]1C2
atizoram
COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1
Rolipram

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Cipamfylline (HEP-688); atizoram (CP-80633); theophylline; isobutylmethylxanthine; Mesopram (ZK-117137); Zardaverine; vinpocetine; Rolipram (ZK-62711); Arofylline (LAS-31025); roflumilast (BY-217); Pumafentrin (BY-343);

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07678363B2uspto-grants-2010_03