Reaktion #2330464

Reaktionsgleichung

5-Trifluoromethyl-1H-(1,2,4)-triazole-3-thiol

heptafluoro-1-iodopropane

triethylamine

→

3-heptafluoropropylsulfanyl-5-trifluoromethyl-1H-(1,2,4)-triazole

Ausbeute 17.6%

Lösungsmittel

DMF

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water and saturated aqueous solution of sodium chloride
2. 2
   TrocknenAfter drying the organic layer with magnesium sulfate
3. 3
   workup.DISTILLATIONthe solvent was distilled off under the reduced pressure

Vorschrift

5-Trifluoromethyl-1H-(1,2,4)-triazole-3-thiol (11.0 g), heptafluoro-1-iodopropane (3.5 g) and triethylamine (0.90 g) were stirred in DMF (10 ml) at 90° C. for 24 hours. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 3-heptafluoropropylsulfanyl-5-trifluoromethyl-1H-(1,2,4)-triazole (0.70 g).

Quelle