Reaktion #2329770

Reaktionsgleichung

Nitrile

(E)-4-(3-(benzyloxy)phenyl)-4-methylpent-2-ene nitrile

ammonia

→

amine

Ausbeute 92.0%

(E)-4-(3-(benzyloxy)phenyl)-4-methylpent-2-en-1-amine

Ausbeute 92.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction mass
2. 2
   Filtrationwas filtered
3. 3
   Einengenthe filtrate was concentrated under reduced pressure

Vorschrift

Nitrile derivative XXXIV (120 g, 0.43 mol), Raney Ni (30 mL) and ammonia in methanol (750 mL) were placed in a hydrogenator, 15 psi pressure of H2 gas was applied at 60° C. for 12 h. Reaction mass was filtered and the filtrate was concentrated under reduced pressure to give 110 g crude amine XXXV (92%). M+1=282

Quelle