Reaktion #2329549

ord-1c874f66717b4889a0f0b0cb37ee8956

Reaktionsgleichung

N#Cc1ccc2c(c1)cc(C(=O)O)n2Cc1cccc(OC(F)(F)F)c1
5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid
Cl.N[C@@H]1CCC[C@H]1O
trans-2-aminocyclopentanol hydrochloride
→
N#Cc1ccc2c(c1)cc(C(=O)N[C@@H]1CCC[C@H]1O)n2Cc1cccc(OC(F)(F)F)c1
title compound
N#Cc1ccc2c(c1)cc(C(=O)N[C@@H]1CCC[C@H]1O)n2Cc1cccc(OC(F)(F)F)c1
trans-5-Cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (2-hydroxy-cyclopentyl)amide

Edukte

N#Cc1ccc2c(c1)cc(C(=O)O)n2Cc1cccc(OC(F)(F)F)c1
5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid
Cl.N[C@@H]1CCC[C@H]1O
trans-2-aminocyclopentanol hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared using 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid [prepared from 3-(trifluoromethoxy)benzyl bromide and ethyl 5-cyanoindole-2-carboxylate] and trans-2-aminocyclopentanol hydrochloride in a manner similar to that described in Example 11.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07671080B2uspto-grants-2010_03