Reaktion #2328980

Reaktionsgleichung

water

2,5-Bis[(cyanoethyl)thio]-1,4-phenylenediamine

4-nitrobenzoyl chloride

→

title compound

Ausbeute 61.3%

2,5-bis[(2-cyanoethyl)sulfanyl]-N-(4-nitrobenzoyl)-1,4-phenylenediamine

Ausbeute 61.3%

Lösungsmittel

NMP

NMP

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigepurge
2. 2
   workup.ADDITIONfollowed by addition of freshly distilled triethylamine (TEA) by syringe
3. 3
   workup.ADDITIONwas added into the stirred fed solution drop by drop over a period of 0.5 h
4. 4
   workup.STIRRINGwith stirring
5. 5
   FiltrationThe resultant yellow precipitate was collected by filtration
6. 6
   Waschenby washing with 800 mL of deionized water twice
7. 7
   ExtraktionThe obtained product was extracted with methanol using a Soxhlet extractor for 24 h
8. 8
   SonstigeA yellow solution was collected
9. 9
   Sonstigeevaporated
10. 10
    Sonstigeby drying at 60° C. under vacuum overnight

Vorschrift

2,5-Bis[(cyanoethyl)thio]-1,4-phenylenediamine (13.9 g, 50 mmol) was dissolved in 90 mL of NMP in a 250 mL 3-necked round-bottom flask under nitrogen purge. The resultant clear red solution was cooled to 0-5° C. in an ice bath, followed by addition of freshly distilled triethylamine (TEA) by syringe. After stirring for 10 minutes, a mixture of 4-nitrobenzoyl chloride (10.2 g, 55 mmol) and 90 mL of NMP was added into the stirred fed solution drop by drop over a period of 0.5 h. The resultant solution was stirred at 0-5° C. for 2 h and at room temperature for 1 h, followed by addition of 800 mL of water with stirring. The resultant yellow precipitate was collected by filtration, followed by washing with 800 mL of deionized water twice and 300 mL of methanol once. The obtained product was extracted with methanol using a Soxhlet extractor for 24 h. A yellow solution was collected and evaporated, followed by drying at 60° C. under vacuum overnight, giving the title compound as a red powder (13.1 g, yield 61%).

Quelle