Reaktion #2328893

ord-0a9129a7bc3d42d9a3997e237ba46aaf

Reaktionsgleichung

CN(C)C1CCCN(C(=O)c2ccc3[nH]c(C(=O)O)cc3c2)C1
5-(3-dimethylamino-piperidine-1-carbonyl)-1H-indole-2-carboxylic acid
C1COCCN1
morpholine
CCN=C=NCCCN(C)C.Cl
1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride
→
CN(C)C1CCCN(C(=O)c2ccc3[nH]c(C(=O)N4CCOCC4)cc3c2)C1
title compound
CN(C)C1CCCN(C(=O)c2ccc3[nH]c(C(=O)N4CCOCC4)cc3c2)C1
[5-(3-Dimethylamino-piperidine-1-carbonyl)-1H-indol-2-yl]-morpholin-4-yl-methanone

Edukte

CN(C)C1CCCN(C(=O)c2ccc3[nH]c(C(=O)O)cc3c2)C1
5-(3-dimethylamino-piperidine-1-carbonyl)-1H-indole-2-carboxylic acid
C1COCCN1
morpholine
CCN=C=NCCCN(C)C.Cl
1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was synthesized in analogy to Example 1, from 5-(3-dimethylamino-piperidine-1-carbonyl)-1H-indole-2-carboxylic acid, morpholine and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride, to afford the product as an off-white solid (37%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07723325B2uspto-grants-2010_05