Reaktion #2324

Reaktionsgleichung

Water

Acetyl chloride

4-amino1-benzylpiperidine

triethylamine

→

4-acetylamino-1-benzylpiperidine

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto reach ambient temperature
2. 2
   Sonstigethe organic phase separated
3. 3
   Sonstigedried
4. 4
   Sonstige(MgSO4), and removal of the solvent
5. 5
   Sonstigeby evaporation

Vorschrift

Acetyl chloride (3.95 ml) was added dropwise to a stirred solution of 4-amino1-benzylpiperidine (10.0 g) and triethylamine (7.7 ml) in dry dichloromethane (100 ml) at 4° C. The mixture was allowed to reach ambient temperature and stirred for 16 hours. Water was then added, the organic phase separated and dried (MgSO4), and removal of the solvent by evaporation gave 4-acetylamino-1-benzylpiperidine, 10.23 g, as a light brown solid which was used without further purification: NMR (CDCl3) δ 7.29(5H,m), 5.29(1H,b), 3.79(1H,m), 3.49(2H,s), 2.80(2H,dm), 2.12(2H,dt), 1.95(3H,s), 191(2H,dm), 1.46(2H,dq); m/e 233 (M+H)+.

Quelle