Reaktion #2323812

Reaktionsgleichung

6-Bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione

4-(4-Methyl-piperazin-1-yl)-phenylamine

water

→

6-bromo-4-{[4-(4-methyl-piperazin-1-yl)-phenylamino]-methylene}-4H-isoquinoline-1,3-dione

Ausbeute 75.5%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturUpon cooling to room temperature
2. 2
   Sonstigethe product precipitated out
3. 3
   FiltrationThe precipitate is then filtered off
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried

Vorschrift

To a suspension of crude 6-Bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione (423 mg, 1.5 mmol) in N,N-dimethylformamide (3 mL) is added 4-(4-Methyl-piperazin-1-yl)-phenylamine (290 mg, 1.5 mmol). The reaction mixture is shaken at 115° C. for 1.5 hours. Upon cooling to room temperature and addition of 2 mL of water, the product precipitated out. The precipitate is then filtered off, washed with water, and dried to yield 0.5 g of crude 6-bromo-4-{[4-(4-methyl-piperazin-1-yl)-phenylamino]-methylene}-4H-isoquinoline-1,3-dione, which is used as such for the next reaction.

Quelle