Reaktion #2322355

ord-4f9eb871ce4e4703bfd8391866acd755

Reaktionsgleichung

COc1ccc(Cl)cc1S(=O)(=O)N1CC(C)c2ccc(C(=O)O)cc21
1-(5-Chloro-2-methoxy-benzenesulfonyl)-3-methyl-2,3-dihydro-1H-indole-6-carboxylic acid
CCOC(=O)c1ccc(N)cc1
ethyl 4-aminobenzoate
→
CCOC(=O)c1ccc(NC(=O)c2ccc3c(c2)N(S(=O)(=O)c2cc(Cl)ccc2OC)CC3C)cc1
4-{[1-(5-chloro-2-methoxy-benzenesulfonyl)-3-methyl-2,3-dihydro-1H-indole-6-carbonyl]-amino}-benzoic acid ethyl ester

Edukte

COc1ccc(Cl)cc1S(=O)(=O)N1CC(C)c2ccc(C(=O)O)cc21
1-(5-Chloro-2-methoxy-benzenesulfonyl)-3-methyl-2,3-dihydro-1H-indole-6-carboxylic acid
CCOC(=O)c1ccc(N)cc1
ethyl 4-aminobenzoate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

1-(5-Chloro-2-methoxy-benzenesulfonyl)-3-methyl-2,3-dihydro-1H-indole-6-carboxylic acid was reacted with ethyl 4-aminobenzoate in analogy to example 62, step 4, yielding 4-{[1-(5-chloro-2-methoxy-benzenesulfonyl)-3-methyl-2,3-dihydro-1H-indole-6-carbonyl]-amino}-benzoic acid ethyl ester. White foam, MS (ISP) 529.1 (M+H).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07713996B2uspto-grants-2010_05