Reaktion #2320114

Reaktionsgleichung

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

hydrochloric acid

→

title compound

Ausbeute 82.3%

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine

Ausbeute 82.3%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefor 1 h
2. 2
   Filtrationfiltered through a pad of celite
3. 3
   SonstigeThe solvent was evaporated in vacuum
4. 4
   Sonstigethe residue was purified by flash chromatography (SiO2, CH2Cl2:MeOH, 9:1 (v/v))

Vorschrift

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine (1.45 g) was dissolved in methanol (40 ml). Concentrated hydrochloric acid (0.2 ml) and 50 mg Pd/C, were added. The resulting mixture was hydrogenated under a hydrogen gas pressure (40 psi) for 1 h and then filtered through a pad of celite. The solvent was evaporated in vacuum and the residue was purified by flash chromatography (SiO2, CH2Cl2:MeOH, 9:1 (v/v)) to give the pure title compound (1.2 g). MS m/z (relative intensity, 70 eV) 353 (M+, 16), 262 (20), 91 (bp), 65 (18), 56 (14).

Quelle