Reaktion #2319445

Reaktionsgleichung

4-chloro-α-methylstyrene

m-chloroperbenzoic acid

→

title compound

Ausbeute 52.4%

2-(4-CHLOROPHENYL)-2-METHYLOXIRANE

Ausbeute 52.4%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGStir the reaction mixture for 1 hr by which time all starting material
2. 2
   Sonstigewill haye reacted
3. 3
   Sonstigeto give virtually a single product
4. 4
   SonstigeRemove the m-chlorobenzoic acid
5. 5
   Sonstigeformed
6. 6
   Waschenby washing chloroform solution with aqueous NaHCO3
7. 7
   TrocknenDry the chloroform solution (Na2SO4)
8. 8
   Sonstigeevaporate to dryness
9. 9
   Sonstigeto provide a colorless oil
10. 10
    workup.DISTILLATIONDistill the oil in vacuo (1 mm)
11. 11
    Sonstigecollect fractions
12. 12
    workup.DISTILLATIONdistilling between 65°-72°

Vorschrift

To a stirred and cooled solution (0°-5° C.) of 4-chloro-α-methylstyrene (15.2g) in chloroform (350 mL), add m-chloroperbenzoic acid (21.6 g). Stir the reaction mixture for 1 hr by which time all starting material will haye reacted to give virtually a single product. Remove the m-chlorobenzoic acid formed by washing chloroform solution with aqueous NaHCO3 followed by water (150 mL). Dry the chloroform solution (Na2SO4) and evaporate to dryness to provide a colorless oil. Distill the oil in vacuo (1 mm) and collect fractions distilling between 65°-72° to give the title compound (8.8 g).

Quelle