Reaktion #2315644

Reaktionsgleichung

diethylamine

hexane ethanol diethylamine

hexane ethanol

→

title compound

N-(1,2,3,4-Tetrahydro-1-naphthalenyl)homopiperazine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschento elute
2. 2
   Sonstigematerial (5.3 g), prepared as in Example 2
3. 3
   workup.ADDITIONThe solution containing this enantiomer
4. 4
   Einengenwas concentrated
5. 5
   Sonstigea rotary evaporator

Vorschrift

R(−) N-(1,2,3,4-tetrahydro-1-naphthalenyl)homopiperazine was obtained as the second material to elute on subjecting racemic material (5.3 g), prepared as in Example 2, to preparative Chiral Pak AD HPLC resolution using a hexane/ethanol mixture with modification with diethylamine. The enantiomeric purity was determined on an analytical scale using hexane:ethanol:diethylamine (90:5:.05, v/v) and detection at 220 nm. The solution containing this enantiomer was concentrated using a rotary evaporator to give the title compound (2.65 g), [α]D22−94° (c=0.64, methanol); 98.5% ee.

Quelle