Reaktion #2314289

Reaktionsgleichung

1-(4′-(2-tetrahydropyranyloxy)phenyl)-3-bromopropane

triphenylphosphine

→

[3-(4-[2-Tetrahydropyranyloxy]phenyl)propyl]triphenylphosphonium bromide

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is then cooled to room temperature
2. 2
   FiltrationThe white precipitate is filtered
3. 3
   Waschenwashed with ethyl acetate
4. 4
   Sonstigedried under vacuum

Vorschrift

To a solution of 1-(4′-(2-tetrahydropyranyloxy)phenyl)-3-bromopropane 3C (4.2 g) in anhydrous dimethylformamide (11.3 mL) is added triphenylphosphine (6.12 g). The reaction mixture is stirred under nitrogen at 100° C. overnight. The reaction mixture is then cooled to room temperature. The white precipitate is filtered and washed with ethyl acetate, then dried under vacuum.

Quelle