Reaktion #2314288

Reaktionsgleichung

potassium carbonate

1-(4′-hydroxyphenyl)-3-bromopropane

dihydropyran

→

1-(4′-(2-tetrahydropyranyloxy)phenyl)-3-bromopropane

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto warm to room temperature
2. 2
   FiltrationThe solid is then filtered out
3. 3
   Sonstigethe solvents and residual DHP is removed in vacuo

Vorschrift

To a solution of 1-(4′-hydroxyphenyl)-3-bromopropane 3B (3.56 g) in dichloromethane (11 mL) is added dihydropyran (2.3 mL). The reaction mixture is cooled to 0° C., and three drops of phosphorus oxychloride are added. The reaction mixture is stirred in the ice bath for a further two hours, then gradually allowed to warm to room temperature, where it is allowed to stir overnight. To the reaction mixture is then added potassium carbonate (3 g), and the reaction mixture is stirred an additional hour. The solid is then filtered out, and the solvents and residual DHP is removed in vacuo.

Quelle