Reaktion #2314287

Reaktionsgleichung

3-(4-hydroxyphenyl)-1-propanol

tetrabromomethane

water

→

1-(4′-hydroxyphenyl)-3-bromopropane

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis added
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   WaschenThe combined organic layers are washed with brine
4. 4
   Trocknendried over magnesium sulfate
5. 5
   EinengenThe solution is concentrated in vacuo

Vorschrift

To a solution of 3-(4-hydroxyphenyl)-1-propanol 3A (4.0 g) and tripohenylphosphine (7.96 g) in anhydrous dichloromethane (77 mL), cooled to 0° C., is added, dropwise, a solution of tetrabromomethane (9.59 g) in anhydrous dichloromethane (15.4 mL). The reaction mixture gradually warmed to room temperature and allowed to stir overnight. The solution is then poured into water and extracted with ethyl acetate. The combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

Quelle