Reaktion #2314280

Reaktionsgleichung

water

tosylate

potassium cyanide

→

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

Lösungsmittel

dimethylsulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is cooled to room temperature
2. 2
   Extraktionextracted with hexane
3. 3
   TrocknenThe combined organic layers are dried over magnesium sulfate
4. 4
   Einengenthe solution is concentrated in vacuo

Vorschrift

To a solution of tosylate 1H (R=4-Methyl-3-pentenyl) (20 g) in dimethylsulfoxide (178 mL) is added potassium cyanide (19.4 g). The reaction mixture is heated to 100° C., and the reaction mixture is stirred at that temperature for three hours. The reaction mixture is cooled to room temperature, added to water (300 mL), and extracted with hexane. The combined organic layers are dried over magnesium sulfate and the solution is concentrated in vacuo.

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