Reaktion #2313070

Reaktionsgleichung

α-hexyl-4-nitro-1H-imidazole-1-acetic acid

(-)-cinchonidine

hydrochloric acid

→

(R)-α-hexyl-4-nitro-1H-imidazole-1-acetic acid

Lösungsmittel

triethylamine

ethanol

water

triethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was warmed to about 40°-45° C
2. 2
   Temperaturto cool gradually to ambient temperature with slow stirring
3. 3
   FiltrationThe precipitated salt was filtered
4. 4
   Waschenwashed with about 30 mL of ethanol --H2O(1:2)
5. 5
   Sonstigedried at 50° C. in vacuo to constant weight

Vorschrift

To a suspension of 5.89 g (0.02 mol) of (-)-cinchonidine in 80 mL water was added 2.78 mL (2.02 g, 0.02 mol) triethylamine. The mixture was warmed to about 40°-45° C. A solution of 10.21 g (0.04 mol) of a racemic mixture of α-hexyl-4-nitro-1H-imidazole-1-acetic acid in 40 mL technical grade ethanol was added to the warm suspension with stirring. (The pH of the mixture was adjusted to 6.9-7.4 by addition of triethylamine or aqueous hydrochloric acid as required.) The resulting suspension was then heated to about 85° C. The resulting solution was allowed to cool gradually to ambient temperature with slow stirring. The precipitated salt was filtered, washed with about 30 mL of ethanol --H2O(1:2), and dried at 50° C. in vacuo to constant weight. The reaction produced 9 g of (R)-α-hexyl-4-nitro-1H-imidazole-1-acetic acid)-cinchonidine salt. A portion of the product was converted to the free acid and then derivatized as the methyl ester (diazomethane) and analyzed by HPLC on a chiral column. The analysis indicated that the acid derived from the product had an ee of 94%. Recrystallization of the product salt from ethanol--water 1:1 (13:1 volumes) provided 7.4 g of the pure salt, ee>99% (HPLC), M.Pt. 205° C. (dec). (NMR).

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