Reaktion #2313009

Reaktionsgleichung

4-[3-(1,2-dihydro-2-oxo-1-quinolinyl)propoxy]-alpha-oxobenzeneacetic acid ethyl ester

sodium carbonate

→

4-[3-(1,2-dihydro-2-oxo-1-quinolinyl)propoxy]-alpha-oxobenzeneacetic acid

Ausbeute 72.8%

Lösungsmittel

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter the methanol was removed in vacuo, dichloromethane and water
2. 2
   workup.ADDITIONwere added
3. 3
   Sonstigedried
4. 4
   Sonstigecrystallized from ethyl acetate-tetrahydrofuran

Vorschrift

A solution of 4-[3-(1,2-dihydro-2-oxo-1-quinolinyl)propoxy]-alpha-oxobenzeneacetic acid ethyl ester (0.5 g) in hot methanol (50 mL) was treated with sodium carbonate (0.14 g) in water (1.5 mL), and the reaction was stirred at room temperature for 5 hours. After the methanol was removed in vacuo, dichloromethane and water were added and the rnixmre was acidified with 3N hydrochloric acid. The precipitated solid was faltered off, dried and then crystallized from ethyl acetate-tetrahydrofuran to afford 0.337 g of 4-[3-(1,2-dihydro-2-oxo-1-quinolinyl)propoxy]-alpha-oxobenzeneacetic acid, mp 183°-186° C.

Quelle