Reaktion #2311227
ord-1a9c78e45178455abb479ecc0afe0b19
Reaktionsgleichung
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Aufarbeitung
- 1FiltrationThen, the reaction solution was filtered on Celite
- 2Sonstigethe filtrate was evaporated to the dry state in a rotary evaporator
- 3Sonstigethe thus obtained TLC-uniform, foamy product (74 mg, 98%) was used without further purification in the next stage
Vorschrift
75 mg of 3-methoxy-8β-methyl-estra-1,3,5(10),9(11)-tetraen-17β-ol (7a) was dissolved in a solvent mixture that consists of 3.5 ml of THF and 1.5 ml of methanol and stirred with 75 mg of palladium (10%, on magnesium carbonate) for 3.75 hours at room temperature under hydrogen atmosphere. Then, the reaction solution was filtered on Celite, the filtrate was evaporated to the dry state in a rotary evaporator, and the thus obtained TLC-uniform, foamy product (74 mg, 98%) was used without further purification in the next stage.