Reaktion #2307811

Reaktionsgleichung

sodium hydroxide

ethyl[2-ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetate

Water

ethyl acetate

→

title compound

Ausbeute 64.2%

4-Carboxymethoxy-3-ethoxyphenylboronic acid

Ausbeute 64.2%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe aqueous layer was separated
2. 2
   Waschenwashed with ethyl acetate
3. 3
   workup.ADDITIONmade acidic with the addition of 2 mol/L hydrochloric acid
4. 4
   Extraktionextracted with ethyl acetate
5. 5
   TrocknenThe organic layer was dried over anhydrous magnesium sulfate
6. 6
   SonstigeThe solvent was evaporated under reduced pressure

Vorschrift

A 2 mol/L aqueous solution of sodium hydroxide (2.14 mL) was added to a solution of ethyl[2-ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetate (0.15 g) in ethanol (10 mL), and the resulting mixture was stirred at 60° C. for 3 hrs. Water and ethyl acetate were added to the reaction mixture. The aqueous layer was separated, washed with ethyl acetate, made acidic with the addition of 2 mol/L hydrochloric acid, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the title compound (0.066 g).

Quelle