Reaktion #2300723

Reaktionsgleichung

1,8-diazabicyclo[5.4.0]undec-7-ene

Triethylamine

2,6-dichlorophenylhydrazine-hydrochloride

1,8-Diazabicyclo[5.4.0]undec-7-ene

p-toluenesulfonyl chloride

ethyl acetate

→

2-(2,6-Dichloro-phenyl)-5-phenoxymethyl-2H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwas washed sequentially with 2M HCl and brine
2. 2
   TrocknenThe organic phase was dried (MgSO4)
3. 3
   Sonstigethe filtrate was evaporated at reduced pressure
4. 4
   workup.DISSOLUTIONThe residue was dissolved in DCM (100 mL)
5. 5
   Temperaturthe solution was cooled in ice/water
6. 6
   Sonstigethe coolant removed
7. 7
   TemperaturThe reaction mixture was re-cooled in ice/water
8. 8
   SonstigeThe coolant was removed
9. 9
   workup.STIRRINGthe reaction mixture was stirred at room temperature for 18 h
10. 10
    WaschenThe reaction mixture was washed sequentially with 2M HCl, saturated aqueous sodium hydrogen carbonate and brine
11. 11
    TrocknenThe organic phase was dried (MgSO4)
12. 12
    Sonstigethe filtrate evaporated at reduced pressure
13. 13
    SonstigeThe residue was purified by flash column chromatography (2:1 hexane:ethyl acetate)
14. 14
    Sonstigeto recover the title compound (1.44 g, 37%)

Vorschrift

Triethylamine (2.09 mL, 15.0 mmol) was added to a stirred suspension of the product from step a (10.0 mmol) and 2,6-dichlorophenylhydrazine-hydrochloride (3.20 g, 10.0 mmol) in ethanol (30 mL). The resultant solution was stirred at room temperature for 18 hours. The reaction mixture was diluted with ethyl acetate and was washed sequentially with 2M HCl and brine. The organic phase was dried (MgSO4) and the filtrate was evaporated at reduced pressure. The residue was dissolved in DCM (100 mL) and the solution was cooled in ice/water. 1,8-Diazabicyclo[5.4.0]undec-7-ene (1.84 mL, 12.3 mmol) and p-toluenesulfonyl chloride (2.14 g, 11.2 mmol) were added sequentially, the coolant removed and the reaction mixture was stirred at room temperature for 40 minutes. The reaction mixture was re-cooled in ice/water and further 1,8-diazabicyclo[5.4.0]undec-7-ene (1.84 mL, 12.3 mmol) was added. The coolant was removed and the reaction mixture was stirred at room temperature for 18 h. The reaction mixture was washed sequentially with 2M HCl, saturated aqueous sodium hydrogen carbonate and brine. The organic phase was dried (MgSO4) and the filtrate evaporated at reduced pressure. The residue was purified by flash column chromatography (2:1 hexane:ethyl acetate) to recover the title compound (1.44 g, 37%). 1H NMR (CDCl3) 7.48-7.44 (3H, m), 7.32-7.27 (2H, m), 7.08-6.98 (3H, m), 5.52 (2H, s), 4.49 (2H, q, J=7.2 Hz), 1.41 (3H, t, J=7.2 Hz).

Quelle