Reaktion #2289933

Reaktionsgleichung

H2O

compound 21-1

ethyl trans-4-(4-((2-(2-azido-4-chloropyridin-3-yl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylate

Me3P

→

compound 21-2

Ausbeute 70.8%

ethyl trans-4-(4-((2-(2-amino-4-chloropyridin-3-yl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylate

Ausbeute 70.8%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 16 h
2. 2
   SonstigeThe solvent was removed under reduced pressure
3. 3
   Sonstigethe residue was purified by column chromatography (silica gel, 30% EtOAc/hexane as eluent)

Vorschrift

To a stirred solution of compound 21-1 (60 mg, 0.09 mmol) in THF (5 mL) was added Me3P (1.0 M in THF, 0.18 mL, 0.18 mmol) at 0° C. and mixture was stirred at room temperature for 2 h. H2O (0.06 mL) was added to the reaction mixture at 0° C. and the mixture was stirred at room temperature for 16 h. The solvent was removed under reduced pressure and the residue was purified by column chromatography (silica gel, 30% EtOAc/hexane as eluent) to provide compound 21-2 (40 mg, 69%) as a yellow oil.

Quelle