Reaktion #2289930

Reaktionsgleichung

compound 15-3

ethyl trans-4-(4-((2-(2-chloro-6-methoxyphenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylate

BBr3

→

compound 15-4

Ausbeute 35.0%

ethyl trans-4-(4-((2-(2-chloro-6-hydroxyphenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylate

Ausbeute 35.0%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeSolvent was evaporated under reduced pressure
2. 2
   Sonstigethe obtained residue was purified by column chromatography (silica gel, 30% EtOAc/hexane as eluent)

Vorschrift

To a stirred solution of compound 15-3 (0.25 g, 0.39 mmol) in DCM (10 mL) was added BBr3 (1.0 M in DCM, 3.9 mL, 3.9 mmol) at room temperature and the mixture was stirred for 16 h. Solvent was evaporated under reduced pressure and the obtained residue was purified by column chromatography (silica gel, 30% EtOAc/hexane as eluent) to provide compound 15-4 (85 mg, 35%) as a yellow oil.

Quelle