Reaktion #2289927

Reaktionsgleichung

compound 7-3

ethyl trans-4-(4-((3,5-difluorobenzyl)(2-(2,6-dimethoxyphenyl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylate

BBr3

→

compound 7-4

Ausbeute 73.3%

ethyl trans-4-(4-((3,5-difluorobenzyl)(2-(2-hydroxy-6-methoxyphenyl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylate

Ausbeute 73.3%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeSolvent was evaporated under reduced pressure
2. 2
   Sonstigethe obtained residue was purified by column chromatography (silica gel, 30% EtOAc/hexane as eluent)

Vorschrift

To a stirred solution of compound 7-3 (50 mg, 0.07 mmol) in DCM (5 mL) was added BBr3 (1.0 M in DCM, 1.5 mL, 1.4 mmol) at room temperature and the mixture was stirred for 16 h. Solvent was evaporated under reduced pressure and the obtained residue was purified by column chromatography (silica gel, 30% EtOAc/hexane as eluent) to provide compound 7-4 (32 mg, 65%) as a brown color gum.

Quelle