Reaktion #2288381

ord-3fdafe6202b149a29d2855bb81f7ff56

Reaktionsgleichung

Cn1c(CBr)c(C(=O)c2ccccc2)c(=O)n(C)c1=O
5-Benzoyl-6-(bromomethyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
Cn1c(CBr)c(C(=O)c2ccccc2)c(=O)n(C)c1=O
Intermediate C
Cn1c(CBr)c(C(=O)c2ccccc2)c(=O)n(C)c1=O
5-Benzoyl-6-(bromomethyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
NCC(O)CO
3-aminopropane-1,2-diol
→
Cn1c(=O)c2c(-c3ccccc3)n(CC(O)CO)cc2n(C)c1=O
6-(2,3-Dihydroxypropyl)-1,3-dimethyl-5-phenyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Edukte

—
TEA
Cn1c(CBr)c(C(=O)c2ccccc2)c(=O)n(C)c1=O
5-Benzoyl-6-(bromomethyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
Cn1c(CBr)c(C(=O)c2ccccc2)c(=O)n(C)c1=O
Intermediate C
Cn1c(CBr)c(C(=O)c2ccccc2)c(=O)n(C)c1=O
5-Benzoyl-6-(bromomethyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
NCC(O)CO
3-aminopropane-1,2-diol

Reagenzien

Keine

Lösungsmittel

CCO
EtOH

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturheated
  2. 2
    Temperaturat reflux for 15 mins

Vorschrift

5-Benzoyl-6-(bromomethyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione (Intermediate C)(670 mg, 1.987 mmol), 3-aminopropane-1,2-diol (0.231 ml, 2.98 mmol) and TEA (0.554 ml, 3.97 mmol) were combined in EtOH (15 ml) and heated at reflux for 15 mins.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09359381B2uspto-grants-2016_06