Reaktion #2288299

Reaktionsgleichung

2-amino-4,4,4-trifluorobutyric acid

NaOH

benzyl chloroformate

→

2-(benzyloxycarbonylamino)-4,4,4-trifluorobutanoic acid

Ausbeute 20.1%

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenIt was then washed with EtOAc
2. 2
   ExtraktionThe product was extracted with EtOAc
3. 3
   TrocknenThe EtOAc phase was dried over Na2SO4
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To a solution of 2-amino-4,4,4-trifluorobutyric acid (543 mg, 3.45 mmol) in aq. 1N NaOH (13 mL, 13.0 mmol), a solution of benzyl chloroformate (0.600 mL, 4.26 mmol) in dioxane (5 mL) was added. The mixture was stirred at room temperature for 18 h. It was then washed with EtOAc. The aqueous solution was acidified to pH 1-2 with 6N HCl. The product was extracted with EtOAc. The EtOAc phase was dried over Na2SO4, concentrated in vacuo to give 2-(benzyloxycarbonylamino)-4,4,4-trifluorobutanoic acid (202 mg).

Quelle